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Biologically inspired model of path integration based on head direction cells and grid cells
Yang ZHOU,De-wei WU
《信息与电子工程前沿(英文)》 2016年 第17卷 第5期 页码 435-448 doi: 10.1631/FITEE.1500364
关键词: Head direction cells (HDCs) Grid cells (GCs) Path integration Bionic navigation
Expression pattern and regulation of head-to-head genes
Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG
《农业科学与工程前沿(英文)》 2014年 第1卷 第2期 页码 130-136 doi: 10.15302/J-FASE-2014013
Basic consideration of research strategies for head and neck cancer
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 339-353 doi: 10.1007/s11684-012-0213-7
Head and neck cancer (HNC) consists of a group of malignancies affecting closely related anatomical regions of the upper aerodigestive tract (UADT), including the oral cavity, salivary glands, upper and lower jaw bones and facial skin; the nasal cavity, paranasal sinuses, pharynx, larynx and thyroid gland (although the latter is often excluded and considered as part of endocrine neoplasms). Of these, 90% of HNCs are histologically squamous cell carcinomas originating from the mucosal lining. These malignancies are strongly associated with certain environmental and life-style risk factors, principally tobacco in both smoked and smokeless forms, excessive alcohol consumption, diets poor in antioxidants and essential micronutrients, UV light, chemicals used in certain workplaces, and viruses, principally certain strains of human papillomavirus (HPV) and Epstein-Barr virus (EBV). These cancers are frequently aggressive in their biological behaviour with local invasion and metastasis to lymph nodes in the neck. Since most patients are already at late stages of disease at the time of diagnosis, the desirable practice of early diagnosis (first sign of the malignant lesion at an initial stage ) and early treatment, a critical priority to save lives and retain quality of life, is difficult to implement. Thus, primary prevention has been set as a key goal. This article aims to reinforce the basic knowledge of aetiology, key risk factors related to the development of head and neck cancer, basic features of clinical appearance of this group of cancers, and strategies for prevention and early detection. We also suggest basic research strategies on the basis of current knowledge, which should ultimately lead to the improvement of clinical management.
关键词: clinical management head and neck cancer prevention and early detection research strategies risk factors
《结构与土木工程前沿(英文)》 页码 1163-1187 doi: 10.1007/s11709-023-0987-5
关键词: cast-in anchor concrete cone capacity geopolymer concrete head size surface crack anchor profile
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《医学前沿(英文)》 2017年 第11卷 第2期 页码 239-246 doi: 10.1007/s11684-017-0509-8
Patients undergoing major oncological surgery for head and neck cancer (SHNC) have a particularly high risk of nosocomial infections. We aimed to identify risk factors for ventilator-associated pneumonia (VAP) in patients undergoing SHNC. The study included 465 patients who underwent SHNC between June 2011 and June 2014. The rate of VAP, risk factors for VAP, and biological aspects of VAP were retrospectively evaluated. The incidence of VAP was 19.6% (n=95) in patients who required more than 48 h of mechanical ventilation. Staphylococcus (37.7%), Enterobacteriaceae (32.1%), Pseudomonas(20.8%), and Haemophilus (16.9%) were the major bacterial species that caused VAP. The independent risk factors for VAP were advanced age, current smoking status, chronic obstructive pulmonary disease, and a higher simplified acute physiology score system II upon admission. Tracheostomy was an independent protective factor for VAP. The median length of stay in the ICU for patients who did or did not develop VAP was 8.0 and 6.5 days, respectively (P=0.006). Mortality among patients who did or did not develop VAP was 16.8% and 8.4%, respectively (P<0.001). The potential economic impact of VAP was high because of the significantly extended duration of ventilation. A predictive regression model was developed with a sensitivity of 95.3% and a specificity of 69.4%. VAP is common in patients who are undergoing SHNC and who require more than 48 h of mechanical ventilation. Therefore, innovative preventive measures should be developed and applied in this high-risk population.
关键词: ventilator-associated pneumonia (VAP) pneumonia risk factors surgery for head and neck cancer (SHNC)
Model test study for ice force on the bank-head of the lead-navigating bank
SONG An, SUN Jinliang, LU Hai, WANG Yi′an
《结构与土木工程前沿(英文)》 2007年 第1卷 第2期 页码 222-228 doi: 10.1007/s11709-007-0027-x
关键词: comparison lead-navigating bank vertical bank-head certain Preliminary
Ultramicrostructure and clinical implications of satellite foci in front of the head of pterygium
LIU Haixia, XIANG Nan, ZHOU Xiongwu, HU Weikun, LI Guigang, ZHANG Hong
《医学前沿(英文)》 2007年 第1卷 第2期 页码 211-214 doi: 10.1007/s11684-007-0040-4
Qualitative analysis of direction of public hospital reforms in China
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《医学前沿(英文)》 2018年 第12卷 第2期 页码 218-223 doi: 10.1007/s11684-017-0534-7
Reforms in public hospitals are among the most important improvements in China’s health care system over the last two decades. However, the reforms that should be implemented in public hospitals are unclear. Thus, a feasible direction of reforms in Chinese public hospitals is suggested and reliable policy suggestions are provided for the government to reform public hospitals. The data used in this study were mainly derived from a qualitative study. Focus group discussions and in-depth interviews were conducted in Shanghai, Guangdong, and Gansu between May and December 2014. Government funding accounted for approximately eight percent of the total annual revenue of public hospitals in China, and the insufficient government subsidy considerably affects the operation mechanism of public hospitals. However, solely increasing this subsidy cannot address the inappropriate incentives of public hospitals in China. The most crucial step in setting the direction of reforms in public hospitals in China is transforming inappropriate incentives by implementing a new evaluation index system for directors and physicians in public hospitals.
关键词: public hospital government hospital public funding operation mechanism
刘宏民,姚双吉,杨利坡,庞志峰,李双来,刘武斌,闫胜友,褚建东
《中国工程科学》 2006年 第8卷 第11期 页码 80-85
针对唐钢高线吐丝机存在的吐丝质量问题,采用三次样条拟合现场实测数据得到吐丝管曲线方程;根据吐丝管中线材的速度和受力模型,分析线材在吐丝管中的运动状态,研究吐丝管空间曲线对吐丝质量的影响,得到吐丝管空间曲率波动过大和出口速度变化过快是导致吐丝质量不好的主要原因;通过改善吐丝管空间曲线和规范煨管工艺制度,显著改善了甩尾、吐圈摆动等吐丝质量,吐丝管寿命提高了1倍。
张玉全,郑源,孙科,杨春霞,罗红英
《中国工程科学》 2018年 第20卷 第3期 页码 90-95 doi: 10.15302/J-SSCAE-2018.03.013
我国水能资源丰富,开发水力发电技术是增加可再生能源供应、优化能源结构、缓解环境问题的优先选择。本文着眼于我国丰富的微水头资源,梳理河流、运河、水库、电厂尾水、管道供水、城市废水、海洋新能源等微水头资源需求和应用特点,总结适合开阔流域和封闭流域特点的两型微水头水力发电水轮机,对形成动势能结合型微水头水轮机设计方法和研究其流动特征和机理提供基础。介绍了微水头资源评估和水力发电水轮机研究的趋势,并对今后研究方向提出了建议。
许维青,韩福忠
《中国工程科学》 2010年 第12卷 第12期 页码 56-58
北京地下直径线盾构独头掘进距离达5.2 km,因此隧道贯通精度控制难度大。通过测量精度分析,单纯通过导线测量已不能满足设计规定的贯通限差要求,施工中通过导线直接传递定向、洞内加测陀螺边、地上地下控制网紧密联系等辅助方法,提高了贯通横向误差的精度,达到了预期效果。
Porcine pluripotent stem cells: progress, challenges and prospects
Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU
《农业科学与工程前沿(英文)》 2019年 第6卷 第1期 页码 8-27 doi: 10.15302/J-FASE-2018233
Pluripotent stem cells (PSCs) are characterized by their capacity for high self-renewal and multiple differentiation potential and include embryonic stem cells, embryonic germ cells and induced PSCs. PSCs provide a very suitable model for the studies of human diseases, drugs screening, regenerative medicine and developmental biology research. Pigs are considered as an ideal model for preclinical development of human xenotransplantation, therapeutic approaches and regenerative medicine because of their size and physiological similarity to humans. However, lack of knowledge about the derivation, characterization and pluripotency mechanisms of porcine PSCs hinders progress in these biotechnologies. In this review, we discuss the latest progress on porcine PSCs generation, evaluation criteria for pluripotency, the scientific and technical questions arising from these studies. We also introduce our perspectives on porcine PSC research, in the hope of providing new ideas for generating naive porcine PSCs and animal breeding.
关键词: embryonic germ cells embryonic stem cells induced pluripotent stem cells pigs pluripotent stem cells
Determination of telomerase activity in stem cells and non-stem cells of breast cancer
LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao
《医学前沿(英文)》 2007年 第1卷 第3期 页码 294-298 doi: 10.1007/s11684-007-0056-9
标题 作者 时间 类型 操作
Biologically inspired model of path integration based on head direction cells and grid cells
Yang ZHOU,De-wei WU
期刊论文
Expression pattern and regulation of head-to-head genes
Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG
期刊论文
Influence of surface cracking, anchor head profile, and anchor head size on cast-in headed anchors in
期刊论文
factors for ventilator-associated pneumonia among patients undergoing major oncological surgery for head
null
期刊论文
Model test study for ice force on the bank-head of the lead-navigating bank
SONG An, SUN Jinliang, LU Hai, WANG Yi′an
期刊论文
Ultramicrostructure and clinical implications of satellite foci in front of the head of pterygium
LIU Haixia, XIANG Nan, ZHOU Xiongwu, HU Weikun, LI Guigang, ZHANG Hong
期刊论文
Porcine pluripotent stem cells: progress, challenges and prospects
Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU
期刊论文